I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 11 studies | 77% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| goblet cell | 11 studies | 77% ± 11% |
Insufficient scRNA-seq data for expression of CLCA1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 94% | 21888.64 | 910 / 966 | 54% | 240.78 | 286 / 527 |
| stomach | 53% | 10.49 | 191 / 359 | 38% | 89.36 | 110 / 286 |
| bladder | 52% | 5.24 | 11 / 21 | 17% | 53.17 | 86 / 504 |
| pancreas | 52% | 5.46 | 170 / 328 | 17% | 83.96 | 31 / 178 |
| ovary | 69% | 8.88 | 124 / 180 | 0% | 0.11 | 1 / 430 |
| spleen | 61% | 6.87 | 147 / 241 | 0% | 0 | 0 / 0 |
| uterus | 59% | 9.42 | 100 / 170 | 0% | 0.16 | 2 / 459 |
| prostate | 53% | 11.12 | 130 / 245 | 0% | 0.34 | 2 / 502 |
| adrenal gland | 52% | 5.27 | 135 / 258 | 0% | 0 | 0 / 230 |
| esophagus | 45% | 12.32 | 657 / 1445 | 5% | 4.67 | 10 / 183 |
| liver | 43% | 5.04 | 97 / 226 | 0% | 0.12 | 2 / 406 |
| thymus | 40% | 3.80 | 264 / 653 | 0% | 0 | 0 / 605 |
| heart | 40% | 3.72 | 344 / 861 | 0% | 0 | 0 / 0 |
| lung | 32% | 4.31 | 186 / 578 | 3% | 1.65 | 34 / 1155 |
| breast | 35% | 57.62 | 159 / 459 | 0% | 0.00 | 1 / 1118 |
| skin | 31% | 3.50 | 569 / 1809 | 0% | 0.01 | 1 / 472 |
| brain | 31% | 2.58 | 812 / 2642 | 0% | 0 | 0 / 705 |
| kidney | 29% | 2.11 | 26 / 89 | 0% | 0.02 | 3 / 901 |
| blood vessel | 29% | 3.29 | 388 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 27% | 5.28 | 328 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 25% | 2.13 | 229 / 929 | 0% | 0 | 0 / 0 |
| muscle | 22% | 2.83 | 179 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0006508 | Biological process | proteolysis |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0005902 | Cellular component | microvillus |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042589 | Cellular component | zymogen granule membrane |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0005229 | Molecular function | intracellularly calcium-gated chloride channel activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | CLCA1 |
| Protein name | Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1) |
| Synonyms | CACC1 |
| Description | FUNCTION: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. . |
| Accessions | ENST00000234701.7 A8K7I4 ENST00000394711.2 |
