CKAP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007019Biological processmicrotubule depolymerization
GO_0050658Biological processRNA transport
GO_0030951Biological processestablishment or maintenance of microtubule cytoskeleton polarity
GO_0007052Biological processmitotic spindle organization
GO_0051298Biological processcentrosome duplication
GO_0051301Biological processcell division
GO_0007098Biological processcentrosome cycle
GO_0046785Biological processmicrotubule polymerization
GO_0090063Biological processpositive regulation of microtubule nucleation
GO_0007051Biological processspindle organization
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0000922Cellular componentspindle pole
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0035371Cellular componentmicrotubule plus-end
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0061863Molecular functionmicrotubule plus end polymerase
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0045296Molecular functioncadherin binding
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCKAP5
Protein nameCytoskeleton associated protein 5
CKAP5 protein
Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)
SynonymsKIAA0097
DescriptionFUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension . Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments . .

AccessionsENST00000312055.9 [Q14008-2]
ENST00000529230.6 [Q14008-1]
H0YEK7
E9PQH5
H0YDX5
ENST00000525896.1
ENST00000527333.5
ENST00000526876.2
Q8IYN5
H0YCF6
Q14008
ENST00000354558.7 [Q14008-2]
ENST00000526496.1