CIP2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CIP2A at tissue level.

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0141112Biological processbroken chromosome clustering
GO_0051276Biological processchromosome organization
GO_0005694Cellular componentchromosome
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0004864Molecular functionprotein phosphatase inhibitor activity
GO_0045296Molecular functioncadherin binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCIP2A
Protein nameNOCIVA
Cellular inhibitor of PP2A
Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)
SynonymsKIAA1524
DescriptionFUNCTION: Acts as an inhibitor of protein phosphatase PP2A . Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies . Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei . Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss . .

AccessionsF8WF26
ENST00000491772.5 [Q8TCG1-2]
ENST00000468953.1
ENST00000481530.5
A0A894J8Q9
ENST00000625495.1
ENST00000295746.13 [Q8TCG1-1]
F8WAX6
Q8TCG1