CHTF8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHTF8 at tissue level.

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006260Biological processDNA replication
GO_0007064Biological processmitotic sister chromatid cohesion
GO_1900264Biological processpositive regulation of DNA-directed DNA polymerase activity
GO_0005654Cellular componentnucleoplasm
GO_0031390Cellular componentCtf18 RFC-like complex
GO_0003677Molecular functionDNA binding
GO_0003689Molecular functionDNA clamp loader activity
GO_0017116Molecular functionsingle-stranded DNA helicase activity

IV. Literature review

[source]
Gene nameCHTF8
Protein nameChromosome transmission fidelity factor 8
Alternative protein CHTF8
Chromosome transmission fidelity protein 8 homolog (hCTF8)
SynonymsCTF8
DescriptionFUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. .

AccessionsENST00000523421.5
ENST00000522091.1
ENST00000519534.1
J3KSJ7
ENST00000518041.5
P0CG13
L0R4W3
E5RGY5
ENST00000398235.6
H3BQB7
ENST00000448552.7
E5RHL4