CHST9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030203Biological processglycosaminoglycan metabolic process
GO_0042446Biological processhormone biosynthetic process
GO_0030166Biological processproteoglycan biosynthetic process
GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0006790Biological processsulfur compound metabolic process
GO_0016051Biological processcarbohydrate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0001537Molecular functionN-acetylgalactosamine 4-O-sulfotransferase activity
GO_0008146Molecular functionsulfotransferase activity
GO_0047756Molecular functionchondroitin 4-sulfotransferase activity

IV. Literature review

[source]
Gene nameCHST9
Protein nameCarbohydrate sulfotransferase 9 isoform 2
Carbohydrate sulfotransferase 9 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-acetylgalactosamine-4-O-sulfotransferase 2)
Alternative protein CHST9
Carbohydrate sulfotransferase (EC 2.8.2.-)
SynonymsUNQ2549/PRO6175
DescriptionFUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

AccessionsQ7L1S5
ENST00000618847.5 [Q7L1S5-1]
ENST00000580774.2 [Q7L1S5-2]
A0A0S2Z5P0
A0A0S2Z5U9
ENST00000581714.5 [Q7L1S5-1]
L8EAG4