CHST8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST8 at tissue level.

III. Associated gene sets

GO_0042446Biological processhormone biosynthetic process
GO_0030166Biological processproteoglycan biosynthetic process
GO_0006790Biological processsulfur compound metabolic process
GO_0016051Biological processcarbohydrate biosynthetic process
GO_0007417Biological processcentral nervous system development
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0001537Molecular functionN-acetylgalactosamine 4-O-sulfotransferase activity
GO_0008146Molecular functionsulfotransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHST8
Protein nameCarbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1)
Carbohydrate sulfotransferase 8
Synonyms
DescriptionFUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. .

AccessionsENST00000438847.7
ENST00000591231.5
ENST00000434302.5
ENST00000262622.4
K7ENM3
ENST00000650847.1
Q9H2A9