CHST5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CHST5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST5 at tissue level.

III. Associated gene sets

GO_0005975Biological processcarbohydrate metabolic process
GO_0006044Biological processN-acetylglucosamine metabolic process
GO_0006790Biological processsulfur compound metabolic process
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0006477Biological processprotein sulfation
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0008146Molecular functionsulfotransferase activity
GO_0001517Molecular functionN-acetylglucosamine 6-O-sulfotransferase activity

IV. Literature review

[source]
Gene nameCHST5
Protein nameCarbohydrate sulfotransferase 5
Carbohydrate sulfotransferase 5 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha) (GST4-alpha) (Intestinal N-acetylglucosamine-6-O-sulfotransferase) (I-GlcNAc6ST) (Intestinal GlcNAc-6-sulfotransferase) (hIGn6ST) (N-acetylglucosamine 6-O-sulfotransferase 3) (GlcNAc6ST-3) (Gn6st-3)
Synonyms
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. .

AccessionsQ9GZS9
H3BMG8
ENST00000565039.1
ENST00000336257.8 [Q9GZS9-1]