CHST14 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST14 at tissue level.

III. Associated gene sets

GO_0030208Biological processdermatan sulfate biosynthetic process
GO_0050655Biological processdermatan sulfate proteoglycan metabolic process
GO_0016051Biological processcarbohydrate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0070062Cellular componentextracellular exosome
GO_0016020Cellular componentmembrane
GO_0001537Molecular functionN-acetylgalactosamine 4-O-sulfotransferase activity
GO_0042301Molecular functionphosphate ion binding
GO_0008146Molecular functionsulfotransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHST14
Protein nameCarbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1)
Carbohydrate sulfotransferase (EC 2.8.2.-)
SynonymsUNQ1925/PRO4400
D4ST1
DescriptionFUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. .

AccessionsQ8NCH0
H0YN65
ENST00000306243.7
ENST00000559991.1