CHRDL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CHRDL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHRDL2 at tissue level.

III. Associated gene sets

GO_0001503Biological processossification
GO_0030154Biological processcell differentiation
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0051216Biological processcartilage development
GO_0005615Cellular componentextracellular space
GO_0005737Cellular componentcytoplasm
GO_0036122Molecular functionBMP binding

IV. Literature review

[source]
Gene nameCHRDL2
Protein nameChordin like 2 (Chordin-related protein 2 variant III)
Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2)
Chordin like 2
SynonymsCHL2
BNF1
UNQ765/PRO1557
DescriptionFUNCTION: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. .

AccessionsA8MQ10
ENST00000376332.8 [Q6WN34-1]
Q6WN34
ENST00000525413.5
ENST00000529912.5
H0YDT1
ENST00000263671.9 [Q6WN34-2]
ENST00000528789.1
ENST00000534276.5 [Q6WN34-4]
H0YCU0
Q6WN33
ENST00000528471.1 [Q6WN34-5]
ENST00000376324.7