CHPF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0050510Molecular functionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0047238Molecular functionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

IV. Literature review

[source]
Gene nameCHPF
Protein nameHexosyltransferase (EC 2.4.1.-)
Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2)
SynonymsUNQ651/PRO1281
CSS2
DescriptionFUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization . .; FUNCTION: [Isoform 2]: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress. .

AccessionsQ8IZ52
ENST00000691864.1
ENST00000535926.3 [Q8IZ52-4]
ENST00000688634.1
ENST00000243776.11 [Q8IZ52-1]
F8W6H2
A0A8I5QJC8
ENST00000373891.3