Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| neuron | 7 studies | 38% ± 19% | |
| enteroendocrine cell | 7 studies | 67% ± 21% | |
| glutamatergic neuron | 6 studies | 34% ± 10% | |
| pancreatic A cell | 4 studies | 93% ± 9% | |
| type B pancreatic cell | 4 studies | 75% ± 18% | |
| retinal ganglion cell | 4 studies | 57% ± 24% | |
| neuroendocrine cell | 4 studies | 87% ± 5% | |
| pancreatic D cell | 3 studies | 79% ± 7% | |
| GABAergic neuron | 3 studies | 31% ± 2% | |
| interneuron | 3 studies | 29% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 97% | 5072.94 | 318 / 328 | 78% | 343.96 | 138 / 178 |
| brain | 69% | 5587.40 | 1829 / 2642 | 75% | 67.16 | 530 / 705 |
| adrenal gland | 46% | 26632.13 | 119 / 258 | 68% | 27798.41 | 156 / 230 |
| stomach | 82% | 23929.84 | 295 / 359 | 30% | 37.97 | 85 / 286 |
| prostate | 33% | 601.23 | 80 / 245 | 73% | 57.43 | 364 / 502 |
| intestine | 52% | 2716.86 | 499 / 966 | 32% | 52.21 | 168 / 527 |
| bladder | 5% | 83.81 | 1 / 21 | 12% | 18.91 | 60 / 504 |
| esophagus | 2% | 39.99 | 22 / 1445 | 12% | 14.84 | 22 / 183 |
| ovary | 0% | 0 | 0 / 180 | 12% | 9.85 | 53 / 430 |
| lung | 1% | 22.13 | 4 / 578 | 10% | 7.96 | 121 / 1155 |
| uterus | 0% | 0 | 0 / 170 | 10% | 9.83 | 44 / 459 |
| thymus | 8% | 2021.32 | 53 / 653 | 1% | 0.47 | 7 / 605 |
| skin | 0% | 8.14 | 6 / 1809 | 5% | 2.03 | 22 / 472 |
| breast | 0% | 2.19 | 1 / 459 | 5% | 102.17 | 53 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.26 | 1 / 29 |
| liver | 0% | 5.94 | 1 / 226 | 3% | 6.81 | 12 / 406 |
| kidney | 0% | 0 | 0 / 89 | 2% | 0.92 | 16 / 901 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.58 | 1 / 80 |
| adipose | 0% | 7.67 | 3 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 2.19 | 2 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 1.19 | 1 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.89 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0033366 | Biological process | protein localization to secretory granule |
| GO_0050832 | Biological process | defense response to fungus |
| GO_0071880 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| GO_0045087 | Biological process | innate immune response |
| GO_2000707 | Biological process | positive regulation of dense core granule biogenesis |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0002026 | Biological process | regulation of the force of heart contraction |
| GO_0060452 | Biological process | positive regulation of cardiac muscle contraction |
| GO_0046676 | Biological process | negative regulation of insulin secretion |
| GO_0006996 | Biological process | organelle organization |
| GO_0043303 | Biological process | mast cell degranulation |
| GO_0031640 | Biological process | killing of cells of another organism |
| GO_0050830 | Biological process | defense response to Gram-positive bacterium |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0086030 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation |
| GO_1900738 | Biological process | positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_1901899 | Biological process | positive regulation of relaxation of cardiac muscle |
| GO_0033604 | Biological process | negative regulation of catecholamine secretion |
| GO_0002551 | Biological process | mast cell chemotaxis |
| GO_0045576 | Biological process | mast cell activation |
| GO_0098992 | Cellular component | neuronal dense core vesicle |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0042583 | Cellular component | chromaffin granule |
| GO_0030133 | Cellular component | transport vesicle |
| GO_0030141 | Cellular component | secretory granule |
| Gene name | CHGA |
| Protein name | Chromogranin-A Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] |
| Synonyms | hCG_21274 |
| Description | FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist . Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chemokines . Acts as a potent scavenger of free radicals in vitro . May play a role in the regulation of cardiac function and blood pressure . .; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. . FUNCTION: Strongly inhibits glucose induced insulin release from the pancreas. . |
| Accessions | ENST00000334654.4 G3V2Q7 P10645 ENST00000627311.2 ENST00000613166.3 G5E968 ENST00000556076.5 ENST00000216492.10 ENST00000630996.1 |
