Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 28% ± 8% | |
microglial cell | 7 studies | 27% ± 9% | |
glutamatergic neuron | 6 studies | 44% ± 24% | |
GABAergic neuron | 6 studies | 38% ± 21% | |
astrocyte | 6 studies | 32% ± 14% | |
macrophage | 6 studies | 28% ± 9% | |
adipocyte | 5 studies | 21% ± 4% | |
oligodendrocyte | 5 studies | 29% ± 7% | |
myeloid cell | 4 studies | 26% ± 6% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 11% | |
dendritic cell | 4 studies | 24% ± 8% | |
monocyte | 4 studies | 22% ± 6% | |
interneuron | 4 studies | 43% ± 24% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 17% ± 1% | |
classical monocyte | 3 studies | 23% ± 5% | |
non-classical monocyte | 3 studies | 22% ± 8% | |
epithelial cell | 3 studies | 32% ± 11% | |
natural killer cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 28% ± 9% | |
fibroblast | 3 studies | 20% ± 4% | |
lymphocyte | 3 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2491.15 | 245 / 245 | 100% | 4.57 | 502 / 502 |
pancreas | 100% | 1485.23 | 327 / 328 | 100% | 5.98 | 178 / 178 |
thymus | 100% | 2369.57 | 653 / 653 | 100% | 5.35 | 603 / 605 |
kidney | 100% | 1907.57 | 89 / 89 | 100% | 4.67 | 898 / 901 |
breast | 100% | 2200.81 | 459 / 459 | 100% | 5.99 | 1114 / 1118 |
skin | 100% | 2502.56 | 1809 / 1809 | 100% | 6.59 | 470 / 472 |
brain | 100% | 1642.05 | 2629 / 2642 | 100% | 6.56 | 705 / 705 |
ovary | 100% | 1418.49 | 180 / 180 | 99% | 4.45 | 426 / 430 |
bladder | 100% | 2724.00 | 21 / 21 | 99% | 6.86 | 497 / 504 |
uterus | 100% | 2169.78 | 170 / 170 | 98% | 7.16 | 451 / 459 |
adrenal gland | 100% | 1782.04 | 258 / 258 | 98% | 3.93 | 225 / 230 |
lung | 100% | 3144.34 | 578 / 578 | 97% | 6.07 | 1125 / 1155 |
stomach | 100% | 1993.03 | 359 / 359 | 95% | 4.43 | 272 / 286 |
esophagus | 100% | 2623.99 | 1445 / 1445 | 94% | 5.01 | 172 / 183 |
liver | 100% | 1146.33 | 226 / 226 | 91% | 2.98 | 369 / 406 |
intestine | 100% | 2766.42 | 966 / 966 | 90% | 4.09 | 475 / 527 |
adipose | 100% | 2246.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 8.73 | 29 / 29 |
spleen | 100% | 4146.66 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 6.98 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.79 | 1 / 1 |
blood vessel | 100% | 2137.30 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 3347.32 | 923 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 1231.16 | 855 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 3.03 | 76 / 80 |
muscle | 92% | 886.26 | 737 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
GO_0031398 | Biological process | positive regulation of protein ubiquitination |
GO_0051301 | Biological process | cell division |
GO_0044779 | Biological process | meiotic spindle checkpoint signaling |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0007093 | Biological process | mitotic cell cycle checkpoint signaling |
GO_0031648 | Biological process | protein destabilization |
GO_0016605 | Cellular component | PML body |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0000166 | Molecular function | nucleotide binding |
Gene name | CHFR |
Protein name | E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR) Checkpoint with forkhead and ring finger domains |
Synonyms | RNF196 |
Description | FUNCTION: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. . |
Accessions | ENST00000542714.5 ENST00000540963.1 ENST00000315585.11 F5H375 ENST00000443047.6 [Q96EP1-5] A0A087X0W6 ENST00000536932.5 A0A087WUN4 Q96EP1 ENST00000541817.5 F5GWH4 ENST00000266880.11 [Q96EP1-3] F5H829 U3KPU9 A0A096P6K8 ENST00000535527.5 ENST00000432561.6 [Q96EP1-1] ENST00000540537.5 ENST00000544093.5 F5H5P5 ENST00000450056.7 [Q96EP1-2] |