CHAC1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHAC1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	81%	660.68	289 / 359	93%	14.93	267 / 286
lung	74%	262.86	429 / 578	90%	11.26	1044 / 1155
pancreas	70%	700.95	231 / 328	87%	9.61	154 / 178
brain	88%	408.47	2316 / 2642	57%	4.45	401 / 705
intestine	38%	94.02	367 / 966	96%	16.32	505 / 527
prostate	67%	208.38	163 / 245	67%	5.34	336 / 502
esophagus	43%	418.33	616 / 1445	91%	15.02	166 / 183
liver	72%	873.37	162 / 226	61%	11.50	247 / 406
skin	39%	510.18	707 / 1809	89%	21.59	419 / 472
ovary	18%	72.94	32 / 180	96%	17.19	413 / 430
uterus	13%	46.51	22 / 170	89%	12.29	410 / 459
ureter	0%	0	0 / 0	100%	5.75	1 / 1
bladder	14%	54.81	3 / 21	85%	10.89	429 / 504
eye	0%	0	0 / 0	95%	130.37	76 / 80
kidney	60%	197.44	53 / 89	32%	3.67	284 / 901
muscle	89%	4353.81	712 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	11.51	39 / 45
adrenal gland	15%	54.08	39 / 258	70%	6.76	162 / 230
breast	25%	89.56	115 / 459	53%	4.66	596 / 1118
thymus	29%	168.58	191 / 653	30%	2.67	184 / 605
spleen	56%	115.78	135 / 241	0%	0	0 / 0
adipose	49%	580.83	593 / 1204	0%	0	0 / 0
heart	46%	200.35	399 / 861	0%	0	0 / 0
blood vessel	41%	138.47	552 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	34%	1.91	10 / 29
peripheral blood	24%	187.47	220 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0006986	Biological process	response to unfolded protein
GO_0022008	Biological process	neurogenesis
GO_0010955	Biological process	negative regulation of protein processing
GO_0045746	Biological process	negative regulation of Notch signaling pathway
GO_0007219	Biological process	Notch signaling pathway
GO_0006750	Biological process	glutathione biosynthetic process
GO_0006751	Biological process	glutathione catabolic process
GO_0005802	Cellular component	trans-Golgi network
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005112	Molecular function	Notch binding
GO_0061928	Molecular function	glutathione specific gamma-glutamylcyclotransferase activity
GO_0003839	Molecular function	gamma-glutamylcyclotransferase activity
GO_0005515	Molecular function	protein binding

Gene name	CHAC1
Protein name	ChaC glutathione specific gamma-glutamylcyclotransferase 1 Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1)
Synonyms	BOTCH
Description	FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides . Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade . Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos . .
Accessions	H0YK90 ENST00000444189.7 [Q9BUX1-2] ENST00000487220.1 Q9BUX1 ENST00000617768.5 [Q9BUX1-1]

CHAC1 report