CERS5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0014003Biological processoligodendrocyte development
GO_0046513Biological processceramide biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003677Molecular functionDNA binding
GO_0050291Molecular functionsphingosine N-acyltransferase activity

IV. Literature review

[source]
Gene nameCERS5
Protein nameCeramide synthase 5 (LASS5 protein)
Ceramide synthase 5
Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24)
Ceramide synthase 5 (cDNA FLJ59959, moderately similar to LAG1 longevity assurance homolog 5)
SynonymsLASS5
DescriptionFUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). .

AccessionsENST00000550258.5
ENST00000547455.5
F8VY42
ENST00000438450.6
F8VXY1
ENST00000422340.6 [Q8N5B7-2]
Q8N5B7
Q49AQ3
F8W1N7
ENST00000542320.5
F8W1Z3
H0YHK2
ENST00000553122.5
ENST00000317551.12 [Q8N5B7-1]
H0YI10
ENST00000550919.5
ENST00000549389.5
F8W1K4
B4DQR7
ENST00000551697.5
ENST00000550547.5
H0YHG4
ENST00000550899.1
ENST00000547800.2
F8VSK7
ENST00000380189.8
F8VQZ6
ENST00000546514.1
ENST00000547787.5
H0YIG1