CERS1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CERS1 at tissue level.

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0072721Biological processcellular response to dithiothreitol
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0051974Biological processnegative regulation of telomerase activity
GO_0071492Biological processcellular response to UV-A
GO_0036146Biological processcellular response to mycotoxin
GO_0046513Biological processceramide biosynthetic process
GO_1901526Biological processpositive regulation of mitophagy
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0050291Molecular functionsphingosine N-acyltransferase activity

IV. Literature review

[source]
Gene nameCERS1
Protein nameCeramide synthase 1
Ceramide synthase 1 (CerS1) (LAG1 longevity assurance homolog 1) (Longevity assurance gene 1 protein homolog 1) (Protein UOG-1) (Sphingoid base N-stearoyltransferase CERS1) (EC 2.3.1.299)
Ceramide synthase 1 (LASS1 protein)
SynonymsLASS1
UOG1
LAG1
DescriptionFUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) . N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria . .

AccessionsENST00000429504.6 [P27544-2]
ENST00000623882.4 [P27544-1]
P27544
ENST00000596048.1
Q5XG75
M0R0T2
ENST00000542296.6