CERK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016310Biological processphosphorylation
GO_0006672Biological processceramide metabolic process
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005524Molecular functionATP binding
GO_0102773Molecular functiondihydroceramide kinase activity
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0001729Molecular functionceramide kinase activity

IV. Literature review

[source]
Gene nameCERK
Protein nameCeramide kinase (cDNA: FLJ23239 fis, clone COL01248)
CERK protein
Ceramide kinase
Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)
SynonymsKIAA1646
DescriptionFUNCTION: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate . Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines . Shows a greater preference for D-erythro isomer of ceramides . Binds phosphoinositides . .

AccessionsF8WFD8
Q9H5N7
Q8TCT0
Q6I9Z0
ENST00000216264.13 [Q8TCT0-1]
ENST00000443629.5