I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 4 studies | 20% ± 5% | |
| cardiac muscle cell | 3 studies | 17% ± 1% | |
| GABAergic neuron | 3 studies | 21% ± 5% | |
| glutamatergic neuron | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 4 studies | 20% ± 5% | |
| cardiac muscle cell | 3 studies | 17% ± 1% | |
| GABAergic neuron | 3 studies | 21% ± 5% | |
| glutamatergic neuron | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 99% | 923.67 | 1429 / 1445 | 100% | 16.95 | 183 / 183 |
| skin | 100% | 1395.11 | 1804 / 1809 | 99% | 17.75 | 465 / 472 |
| lung | 99% | 922.93 | 571 / 578 | 99% | 17.50 | 1146 / 1155 |
| intestine | 97% | 826.56 | 937 / 966 | 98% | 12.85 | 519 / 527 |
| brain | 96% | 1133.29 | 2545 / 2642 | 98% | 10.12 | 692 / 705 |
| thymus | 100% | 1588.97 | 653 / 653 | 94% | 8.95 | 571 / 605 |
| bladder | 95% | 614.90 | 20 / 21 | 99% | 14.90 | 497 / 504 |
| uterus | 96% | 649.15 | 163 / 170 | 97% | 20.64 | 447 / 459 |
| stomach | 94% | 678.07 | 338 / 359 | 99% | 11.64 | 282 / 286 |
| breast | 92% | 647.04 | 423 / 459 | 99% | 18.40 | 1108 / 1118 |
| pancreas | 93% | 549.75 | 304 / 328 | 96% | 8.50 | 170 / 178 |
| kidney | 100% | 987.57 | 89 / 89 | 84% | 5.53 | 760 / 901 |
| ovary | 82% | 565.54 | 148 / 180 | 98% | 12.18 | 422 / 430 |
| prostate | 92% | 575.62 | 226 / 245 | 86% | 5.79 | 432 / 502 |
| adrenal gland | 95% | 639.07 | 245 / 258 | 75% | 5.59 | 173 / 230 |
| liver | 96% | 596.52 | 216 / 226 | 71% | 5.37 | 287 / 406 |
| muscle | 100% | 5548.83 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1154.78 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 23.72 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.80 | 1 / 1 |
| heart | 95% | 2355.12 | 821 / 861 | 0% | 0 | 0 / 0 |
| adipose | 88% | 488.05 | 1065 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 10.91 | 25 / 29 |
| eye | 0% | 0 | 0 / 0 | 71% | 4.79 | 57 / 80 |
| peripheral blood | 67% | 874.63 | 626 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 38% | 171.55 | 503 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0046602 | Biological process | regulation of mitotic centrosome separation |
| GO_0006469 | Biological process | negative regulation of protein kinase activity |
| GO_0098534 | Biological process | centriole assembly |
| GO_0016477 | Biological process | cell migration |
| GO_0007099 | Biological process | centriole replication |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0005814 | Cellular component | centriole |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005813 | Cellular component | centrosome |
| GO_0000242 | Cellular component | pericentriolar material |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0000922 | Cellular component | spindle pole |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CEP85 |
| Protein name | Centrosomal protein 85 Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) |
| Synonyms | CCDC21 |
| Description | FUNCTION: Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility . Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity . . |
| Accessions | ENST00000252992.8 [Q6P2H3-1] Q6P2H3 ENST00000640292.2 [Q6P2H3-4] ENST00000451429.8 [Q6P2H3-2] H7BZW2 ENST00000453146.1 |
