CEP295 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901985Biological processpositive regulation of protein acetylation
GO_1903724Biological processpositive regulation of centriole elongation
GO_0010825Biological processpositive regulation of centrosome duplication
GO_0046599Biological processregulation of centriole replication
GO_0007099Biological processcentriole replication
GO_1904951Biological processpositive regulation of establishment of protein localization
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_1990498Cellular componentmitotic spindle microtubule
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameCEP295
Protein nameCentrosomal protein 295
Centrosomal protein of 295 kDa
SynonymsKIAA1731
DescriptionFUNCTION: Centriole-enriched microtubule-binding protein involved in centriole biogenesis . Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure . Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles . Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement . Binds to and stabilizes centriolar microtubule . .

AccessionsENST00000325212.11 [Q9C0D2-1]
H0YDK0
Q9C0D2
E9PJG3
E9PM20
ENST00000531700.5 [Q9C0D2-2]
ENST00000529185.1
ENST00000531404.1
ENST00000530425.1
E9PJY3
ENST00000531877.1