CEP19 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CEP19 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0034454Biological processmicrotubule anchoring at centrosome
GO_0097712Biological processvesicle targeting, trans-Golgi to periciliary membrane compartment
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0005654Cellular componentnucleoplasm
GO_0000922Cellular componentspindle pole
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCEP19
Protein nameCentrosomal protein of 19 kDa
Centrosomal protein of 19 kDa (Cep19)
SynonymsC3orf34
HSD5
DescriptionFUNCTION: Required for ciliation . Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia . Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes . .

AccessionsENST00000399942.4
ENST00000409690.5
Q96LK0
A8MX07