CEP135 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902857Biological processpositive regulation of non-motile cilium assembly
GO_0010457Biological processcentriole-centriole cohesion
GO_0007099Biological processcentriole replication
GO_1904951Biological processpositive regulation of establishment of protein localization
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding
GO_0015631Molecular functiontubulin binding

IV. Literature review

[source]
Gene nameCEP135
Protein nameCentrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4)
SynonymsKIAA0635
CEP4
DescriptionFUNCTION: Centrosomal microtubule-binding protein involved in centriole biogenesis . Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner . .

AccessionsENST00000257287.5 [Q66GS9-1]
ENST00000422247.6 [Q66GS9-2]
Q66GS9