CENPU report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CENPU at tissue level.

III. Associated gene sets

GO_0043009Biological processchordate embryonic development
GO_0007059Biological processchromosome segregation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0034451Cellular componentcentriolar satellite
GO_0000939Cellular componentinner kinetochore
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENPU
Protein nameCentromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1)
Centromere protein U (MLF1-interacting protein)
SynonymsICEN24
PBIP1
MLF1IP
KLIP1
DescriptionFUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. .

AccessionsD6R9S4
Q71F23
ENST00000510146.5
Q09GN1
ENST00000514781.1
ENST00000281453.10 [Q71F23-1]