Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| erythroblast | 5 studies | 38% ± 15% | |
| plasmablast | 4 studies | 31% ± 17% | |
| hematopoietic precursor cell | 4 studies | 20% ± 3% | |
| pro-B cell | 4 studies | 26% ± 7% | |
| megakaryocyte-erythroid progenitor cell | 4 studies | 32% ± 15% | |
| B cell | 3 studies | 22% ± 3% | |
| erythrocyte | 3 studies | 39% ± 14% | |
| transit amplifying cell | 3 studies | 39% ± 22% | |
| precursor B cell | 3 studies | 33% ± 2% | |
| natural killer cell | 3 studies | 32% ± 10% | |
| CD8-positive, alpha-beta T cell | 3 studies | 26% ± 5% | |
| T cell | 3 studies | 22% ± 4% |
Insufficient scRNA-seq data for expression of CENPU at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 98% | 877.29 | 1778 / 1809 | 91% | 21.99 | 430 / 472 |
| breast | 83% | 138.25 | 382 / 459 | 98% | 27.48 | 1093 / 1118 |
| lung | 77% | 172.53 | 443 / 578 | 91% | 20.59 | 1054 / 1155 |
| intestine | 64% | 193.06 | 620 / 966 | 93% | 20.82 | 492 / 527 |
| bladder | 62% | 78.57 | 13 / 21 | 95% | 24.54 | 478 / 504 |
| esophagus | 52% | 401.91 | 758 / 1445 | 98% | 23.47 | 179 / 183 |
| stomach | 56% | 148.25 | 202 / 359 | 92% | 18.43 | 263 / 286 |
| uterus | 43% | 60.72 | 73 / 170 | 98% | 42.63 | 451 / 459 |
| ovary | 33% | 52.52 | 60 / 180 | 90% | 13.55 | 387 / 430 |
| prostate | 68% | 102.46 | 166 / 245 | 52% | 5.64 | 262 / 502 |
| adrenal gland | 71% | 113.49 | 184 / 258 | 41% | 5.81 | 94 / 230 |
| pancreas | 29% | 34.05 | 96 / 328 | 75% | 9.59 | 133 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 31.27 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 49.92 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 18.89 | 1 / 1 |
| spleen | 98% | 311.93 | 235 / 241 | 0% | 0 | 0 / 0 |
| liver | 39% | 96.58 | 89 / 226 | 58% | 8.09 | 236 / 406 |
| thymus | 40% | 48.81 | 258 / 653 | 48% | 7.81 | 290 / 605 |
| kidney | 39% | 59.83 | 35 / 89 | 44% | 3.94 | 394 / 901 |
| adipose | 78% | 129.78 | 945 / 1204 | 0% | 0 | 0 / 0 |
| brain | 19% | 20.88 | 495 / 2642 | 51% | 10.84 | 361 / 705 |
| peripheral blood | 62% | 689.15 | 576 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 31% | 39.93 | 418 / 1335 | 0% | 0 | 0 / 0 |
| heart | 24% | 30.67 | 205 / 861 | 0% | 0 | 0 / 0 |
| muscle | 23% | 25.53 | 182 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 20% | 1.46 | 16 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043009 | Biological process | chordate embryonic development |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0000939 | Cellular component | inner kinetochore |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CENPU |
| Protein name | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) Centromere protein U (MLF1-interacting protein) |
| Synonyms | ICEN24 PBIP1 MLF1IP KLIP1 |
| Description | FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. . |
| Accessions | D6R9S4 Q71F23 ENST00000510146.5 Q09GN1 ENST00000514781.1 ENST00000281453.10 [Q71F23-1] |