CENPE report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CENPE at tissue level.

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0000278Biological processmitotic cell cycle
GO_0007059Biological processchromosome segregation
GO_0007052Biological processmitotic spindle organization
GO_0051310Biological processmetaphase chromosome alignment
GO_0051382Biological processkinetochore assembly
GO_0051315Biological processattachment of mitotic spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0007018Biological processmicrotubule-based movement
GO_0007079Biological processmitotic chromosome movement towards spindle pole
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0099607Biological processlateral attachment of mitotic spindle microtubules to kinetochore
GO_0099606Biological processmicrotubule plus-end directed mitotic chromosome migration
GO_0000775Cellular componentchromosome, centromeric region
GO_0030496Cellular componentmidbody
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0000776Cellular componentkinetochore
GO_1990023Cellular componentmitotic spindle midzone
GO_0045171Cellular componentintercellular bridge
GO_0051233Cellular componentspindle midzone
GO_0005828Cellular componentkinetochore microtubule
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0043515Molecular functionkinetochore binding
GO_0003777Molecular functionmicrotubule motor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENPE
Protein nameCentromere protein E
Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE)
Synonyms
DescriptionFUNCTION: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules . The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated . Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends . Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized . Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). .

AccessionsENST00000509823.2
ENST00000265148.9 [Q02224-1]
ENST00000380026.8 [Q02224-3]
D6RHK2
ENST00000514974.1
Q02224
A0A5F9ZH24