CELF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006376Biological processmRNA splice site recognition
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0005575Cellular componentcellular_component
GO_1990904Cellular componentribonucleoprotein complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0036002Molecular functionpre-mRNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameCELF5
Protein nameCUGBP Elav-like family member 5
CUGBP Elav-like family member 5 (cDNA FLJ52259, highly similar to Homo sapiens bruno-like 5, RNA binding protein, mRNA)
CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5)
SynonymsBRUNOL5
DescriptionFUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. .

AccessionsENST00000334293.10
K7ES14
B4DFI3
Q8N6W0
ENST00000541430.6 [Q8N6W0-2]
ENST00000588350.1
ENST00000292672.7 [Q8N6W0-1]