CELF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006376Biological processmRNA splice site recognition
GO_0007283Biological processspermatogenesis
GO_0008380Biological processRNA splicing
GO_0030317Biological processflagellated sperm motility
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0030575Biological processnuclear body organization
GO_0016604Cellular componentnuclear body
GO_1990904Cellular componentribonucleoprotein complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0036002Molecular functionpre-mRNA binding
GO_0097322Molecular function7SK snRNA binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCELF3
Protein nameCUGBP Elav-like family member 3 (CELF-3) (Bruno-like protein 1) (CAG repeat protein 4) (CUG-BP- and ETR-3-like factor 3) (ELAV-type RNA-binding protein 1) (ETR-1) (Expanded repeat domain protein CAG/CTG 4) (RNA-binding protein BRUNOL-1) (Trinucleotide repeat-containing gene 4 protein)
CUG-BP and ETR-3 like factor 3
CUGBP Elav-like family member 3
SynonymsBRUNOL1
CAGH4
TNRC4
ERDA4
DescriptionFUNCTION: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. .

AccessionsQ5SZQ8
ENST00000290583.9 [Q5SZQ8-1]
Q8IZ97
ENST00000290585.8 [Q5SZQ8-4]
H0Y623
ENST00000420342.1