CDK7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDK7 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006281Biological processDNA repair
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0042795Biological processsnRNA transcription by RNA polymerase II
GO_0051301Biological processcell division
GO_0050821Biological processprotein stabilization
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006468Biological processprotein phosphorylation
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070985Cellular componenttranscription factor TFIIK complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0001650Cellular componentfibrillar center
GO_0070516Cellular componentCAK-ERCC2 complex
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0005524Molecular functionATP binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK7
Protein nameCyclin-dependent kinase 7
[RNA-polymerase]-subunit kinase (EC 2.7.11.23)
Cyclin-dependent kinase 7 (EC 2.7.11.23) (Cell division protein kinase 7)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
SynonymsMO15
STK1
hCG_1988840
CAK1
CDKN7
CAK
DescriptionFUNCTION: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts . Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. .

AccessionsD6RGG9
P50613
ENST00000502604.5
ENST00000613505.4
ENST00000622424.4
ENST00000626796.2
D6RAD4
ENST00000629350.2
ENST00000618909.4
ENST00000614881.4
ENST00000510106.5
D6REC6
ENST00000615854.4
ENST00000615305.4
D6RF14
ENST00000514676.5
ENST00000515391.5
D6RI01
ENST00000628367.2
D6R9G1
ENST00000506789.5
ENST00000256443.8
ENST00000617941.4
ENST00000506563.5
D6RIG9
D6R9Z2
ENST00000504147.5
ENST00000515180.5
ENST00000617026.4
A0A0S2Z3F9
ENST00000508726.5
ENST00000614858.4
ENST00000629972.2
D6RFL0
ENST00000617289.4