Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 13 studies | 38% ± 16% | |
astrocyte | 12 studies | 34% ± 15% | |
endothelial cell | 9 studies | 29% ± 13% | |
oligodendrocyte precursor cell | 9 studies | 29% ± 12% | |
glutamatergic neuron | 7 studies | 38% ± 21% | |
GABAergic neuron | 7 studies | 33% ± 17% | |
ciliated cell | 6 studies | 22% ± 5% | |
interneuron | 6 studies | 35% ± 20% | |
macrophage | 6 studies | 25% ± 6% | |
microglial cell | 6 studies | 28% ± 10% | |
epithelial cell | 6 studies | 29% ± 11% | |
neuron | 5 studies | 34% ± 16% | |
lymphocyte | 4 studies | 26% ± 8% | |
monocyte | 4 studies | 18% ± 3% | |
fibroblast | 4 studies | 25% ± 9% | |
hematopoietic precursor cell | 3 studies | 20% ± 3% | |
cardiac muscle cell | 3 studies | 16% ± 0% | |
basal cell | 3 studies | 31% ± 9% | |
respiratory goblet cell | 3 studies | 21% ± 3% | |
hepatocyte | 3 studies | 39% ± 17% | |
ependymal cell | 3 studies | 31% ± 14% | |
leukocyte | 3 studies | 20% ± 2% | |
transit amplifying cell | 3 studies | 40% ± 23% | |
adipocyte | 3 studies | 18% ± 1% | |
smooth muscle cell | 3 studies | 18% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 3639.89 | 459 / 459 | 100% | 28.19 | 1118 / 1118 |
uterus | 100% | 3507.49 | 170 / 170 | 100% | 24.33 | 459 / 459 |
esophagus | 100% | 3101.67 | 1444 / 1445 | 100% | 25.72 | 183 / 183 |
prostate | 100% | 3653.55 | 245 / 245 | 100% | 21.75 | 501 / 502 |
skin | 100% | 4277.23 | 1809 / 1809 | 100% | 25.65 | 471 / 472 |
liver | 100% | 2172.40 | 226 / 226 | 100% | 17.69 | 405 / 406 |
thymus | 100% | 3428.07 | 653 / 653 | 99% | 41.56 | 601 / 605 |
intestine | 100% | 3321.68 | 966 / 966 | 99% | 15.57 | 523 / 527 |
brain | 99% | 2398.32 | 2628 / 2642 | 100% | 21.29 | 703 / 705 |
lung | 100% | 2980.70 | 576 / 578 | 99% | 25.22 | 1147 / 1155 |
stomach | 100% | 2774.74 | 359 / 359 | 99% | 15.71 | 283 / 286 |
bladder | 100% | 3325.24 | 21 / 21 | 99% | 17.26 | 498 / 504 |
ovary | 100% | 4188.81 | 180 / 180 | 98% | 15.98 | 423 / 430 |
adrenal gland | 100% | 3079.74 | 258 / 258 | 97% | 16.31 | 223 / 230 |
kidney | 100% | 1794.43 | 89 / 89 | 96% | 13.05 | 866 / 901 |
pancreas | 96% | 1394.97 | 315 / 328 | 99% | 15.30 | 176 / 178 |
adipose | 100% | 2827.98 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5387.51 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 24.21 | 29 / 29 |
muscle | 100% | 6878.11 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3619.42 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 29.00 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.20 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 25.91 | 79 / 80 |
peripheral blood | 97% | 6731.58 | 904 / 929 | 0% | 0 | 0 / 0 |
heart | 95% | 2722.53 | 819 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045664 | Biological process | regulation of neuron differentiation |
GO_0007059 | Biological process | chromosome segregation |
GO_0000132 | Biological process | establishment of mitotic spindle orientation |
GO_0031116 | Biological process | positive regulation of microtubule polymerization |
GO_0007098 | Biological process | centrosome cycle |
GO_0045665 | Biological process | negative regulation of neuron differentiation |
GO_0022008 | Biological process | neurogenesis |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0046600 | Biological process | negative regulation of centriole replication |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0007420 | Biological process | brain development |
GO_0031023 | Biological process | microtubule organizing center organization |
GO_0090266 | Biological process | regulation of mitotic cell cycle spindle assembly checkpoint |
GO_0001578 | Biological process | microtubule bundle formation |
GO_0007099 | Biological process | centriole replication |
GO_0000931 | Cellular component | gamma-tubulin ring complex |
GO_0097431 | Cellular component | mitotic spindle pole |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005874 | Cellular component | microtubule |
GO_0000922 | Cellular component | spindle pole |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005813 | Cellular component | centrosome |
GO_0035371 | Cellular component | microtubule plus-end |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0030054 | Cellular component | cell junction |
GO_0000242 | Cellular component | pericentriolar material |
GO_0043015 | Molecular function | gamma-tubulin binding |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_0015631 | Molecular function | tubulin binding |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CDK5RAP2 |
Protein name | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) CDK5 regulatory subunit-associated protein 2 CDK5 regulatory subunit associated protein 2 |
Synonyms | CEP215 KIAA1633 hCG_27455 |
Description | FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes . In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery . Required for the recruitment of AKAP9 to centrosomes . Plays a role in neurogenesis (By similarity). . |
Accessions | ENST00000692155.1 A6H8X1 A0A8I5KWN7 A0A8I5KTP5 ENST00000689688.1 Q5JTU8 A0A8I5KXG0 A0A8I5KRU7 Q05CZ3 ENST00000691551.1 ENST00000690814.1 B7ZLE9 ENST00000690646.1 B9EG74 A0A8I5KX24 F8WCI3 ENST00000349780.9 [Q96SN8-1] F8WBJ0 A0A8I5QKL1 ENST00000360822.8 ENST00000686376.1 A0A8I5KXB5 A0A0A0MRG9 F8WF55 ENST00000687024.1 A0A0C4ZLW1 A0A8I5KSG3 A0A8I5KYJ8 ENST00000687279.1 ENST00000687633.1 B1AMJ5 Q96SN8 A0A8I5QJG6 ENST00000425647.1 ENST00000481266.2 ENST00000693386.1 ENST00000416449 ENST00000480112.5 ENST00000473282.6 ENST00000688512.1 ENST00000360190.8 [Q96SN8-4] A0A8I5KPG9 A0A8I5KYS3 ENST00000416449.6 [Q96SN8-2] ENST00000685866.1 ENST00000693728.1 |