CDK5RAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045664Biological processregulation of neuron differentiation
GO_0007059Biological processchromosome segregation
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0007098Biological processcentrosome cycle
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0022008Biological processneurogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0046600Biological processnegative regulation of centriole replication
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0007420Biological processbrain development
GO_0031023Biological processmicrotubule organizing center organization
GO_0090266Biological processregulation of mitotic cell cycle spindle assembly checkpoint
GO_0001578Biological processmicrotubule bundle formation
GO_0007099Biological processcentriole replication
GO_0000931Cellular componentgamma-tubulin ring complex
GO_0097431Cellular componentmitotic spindle pole
GO_0005856Cellular componentcytoskeleton
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0035371Cellular componentmicrotubule plus-end
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030054Cellular componentcell junction
GO_0000242Cellular componentpericentriolar material
GO_0043015Molecular functiongamma-tubulin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0015631Molecular functiontubulin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0008017Molecular functionmicrotubule binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDK5RAP2
Protein nameCDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)
CDK5 regulatory subunit-associated protein 2
CDK5 regulatory subunit associated protein 2
SynonymsCEP215
KIAA1633
hCG_27455
DescriptionFUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes . In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery . Required for the recruitment of AKAP9 to centrosomes . Plays a role in neurogenesis (By similarity). .

AccessionsENST00000692155.1
A6H8X1
A0A8I5KWN7
A0A8I5KTP5
ENST00000689688.1
Q5JTU8
A0A8I5KXG0
A0A8I5KRU7
Q05CZ3
ENST00000691551.1
ENST00000690814.1
B7ZLE9
ENST00000690646.1
B9EG74
A0A8I5KX24
F8WCI3
ENST00000349780.9 [Q96SN8-1]
F8WBJ0
A0A8I5QKL1
ENST00000360822.8
ENST00000686376.1
A0A8I5KXB5
A0A0A0MRG9
F8WF55
ENST00000687024.1
A0A0C4ZLW1
A0A8I5KSG3
A0A8I5KYJ8
ENST00000687279.1
ENST00000687633.1
B1AMJ5
Q96SN8
A0A8I5QJG6
ENST00000425647.1
ENST00000481266.2
ENST00000693386.1
ENST00000416449
ENST00000480112.5
ENST00000473282.6
ENST00000688512.1
ENST00000360190.8 [Q96SN8-4]
A0A8I5KPG9
A0A8I5KYS3
ENST00000416449.6 [Q96SN8-2]
ENST00000685866.1
ENST00000693728.1