CDK20 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDK20 at tissue level.

III. Associated gene sets

GO_0061512Biological processprotein localization to cilium
GO_0021508Biological processfloor plate formation
GO_1903317Biological processregulation of protein maturation
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0051301Biological processcell division
GO_0060021Biological processroof of mouth development
GO_0048706Biological processembryonic skeletal system development
GO_0031076Biological processembryonic camera-type eye development
GO_0001843Biological processneural tube closure
GO_0006468Biological processprotein phosphorylation
GO_0051726Biological processregulation of cell cycle
GO_1990403Biological processembryonic brain development
GO_0005654Cellular componentnucleoplasm
GO_0005929Cellular componentcilium
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK20
Protein nameCyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20)
Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
SynonymsCCRK
hCG_1743717
CDCH
DescriptionFUNCTION: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. .

AccessionsA0A0S2Z566
A0A0S2Z5B6
Q8IZL9
ENST00000375871.8 [Q8IZL9-2]
A0A0S2Z557
A0A0S2Z562
ENST00000336654.9 [Q8IZL9-4]
ENST00000375883.7 [Q8IZL9-5]
A0A0S2Z552
ENST00000605159.5 [Q8IZL9-3]
ENST00000325303.9 [Q8IZL9-1]
A0A0S2Z535