CDC6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CDC6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDC6 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301Biological processcell division
GO_1904117Biological processcellular response to vasopressin
GO_0008156Biological processnegative regulation of DNA replication
GO_0006270Biological processDNA replication initiation
GO_0051984Biological processpositive regulation of chromosome segregation
GO_0033314Biological processmitotic DNA replication checkpoint signaling
GO_0007089Biological processtraversing start control point of mitotic cell cycle
GO_0032467Biological processpositive regulation of cytokinesis
GO_0000076Biological processDNA replication checkpoint signaling
GO_1904385Biological processcellular response to angiotensin
GO_0005730Cellular componentnucleolus
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0005654Cellular componentnucleoplasm
GO_0045171Cellular componentintercellular bridge
GO_0051233Cellular componentspindle midzone
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003688Molecular functionDNA replication origin binding
GO_0019900Molecular functionkinase binding
GO_0000166Molecular functionnucleotide binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameCDC6
Protein nameCell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)
Cell division cycle 6
SynonymsCDC18L
DescriptionFUNCTION: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

AccessionsENST00000209728.9
J3QR52
ENST00000580824.5
J3QLN7
J3KTI7
ENST00000473555.1
ENST00000649662.1
ENST00000577249.1
Q99741