CDC42EP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007266Biological processRho protein signal transduction
GO_0007254Biological processJNK cascade
GO_0008360Biological processregulation of cell shape
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0031274Biological processpositive regulation of pseudopodium assembly
GO_0012505Cellular componentendomembrane system
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameCDC42EP5
Protein nameCdc42 effector protein 5 (Binder of Rho GTPases 3)
Cdc42 effector protein 5
SynonymsCEP5
BORG3
DescriptionFUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity). .

AccessionsENST00000301200.3
ENST00000617756.1
ENST00000611094.1
ENST00000610368.1
Q6NZY7
A0A0G2JPE9
ENST00000619217.1
ENST00000622855.1