CDC34 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDC34 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0035458Biological processcellular response to interferon-beta
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0036211Biological processprotein modification process
GO_0006270Biological processDNA replication initiation
GO_0090261Biological processpositive regulation of inclusion body assembly
GO_0043951Biological processnegative regulation of cAMP-mediated signaling
GO_0070848Biological processresponse to growth factor
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDC34
Protein nameUbiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)
Cell division cycle 34, ubiqiutin conjugating enzyme
SynonymsUBE2R1
UBCH3
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination . Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes . .

AccessionsENST00000586283.6
U3KQP9
U3KPV8
ENST00000607527.5
ENST00000606065.3
P49427
ENST00000215574.9
U3KQ77