CD101 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CD101 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD101 at tissue level.

III. Associated gene sets

GO_0002763Biological processpositive regulation of myeloid leukocyte differentiation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0016812Molecular functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

IV. Literature review

[source]
Gene nameCD101
Protein nameImmunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu-Trp-Ile EWI motif-containing protein 101) (EWI-101) (CD antigen CD101)
CD101 molecule
SynonymsV7
EWI101
IGSF2
DescriptionFUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. .

AccessionsA0A1L7MZP9
ENST00000256652.8
Q93033
ENST00000682167.1
A0A1L7MZR3
ENST00000369470.1
A0A1L7MZY4