I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 6 studies | 23% ± 2% | |
| connective tissue cell | 3 studies | 33% ± 7% | |
| ciliated cell | 3 studies | 23% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 6 studies | 23% ± 2% | |
| connective tissue cell | 3 studies | 33% ± 7% | |
| ciliated cell | 3 studies | 23% ± 6% |
Insufficient scRNA-seq data for expression of CCDC8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 3853.38 | 180 / 180 | 98% | 60.26 | 423 / 430 |
| thymus | 100% | 1555.12 | 653 / 653 | 96% | 57.87 | 581 / 605 |
| pancreas | 99% | 1193.20 | 325 / 328 | 87% | 20.06 | 155 / 178 |
| breast | 92% | 1580.11 | 420 / 459 | 73% | 17.15 | 813 / 1118 |
| prostate | 99% | 1097.95 | 242 / 245 | 65% | 8.91 | 324 / 502 |
| kidney | 96% | 892.13 | 85 / 89 | 64% | 20.60 | 578 / 901 |
| uterus | 100% | 2294.26 | 170 / 170 | 57% | 27.70 | 260 / 459 |
| lung | 92% | 728.54 | 534 / 578 | 52% | 12.87 | 606 / 1155 |
| skin | 84% | 767.25 | 1515 / 1809 | 58% | 18.59 | 274 / 472 |
| adrenal gland | 100% | 2566.55 | 257 / 258 | 34% | 19.47 | 78 / 230 |
| bladder | 100% | 1235.71 | 21 / 21 | 32% | 6.18 | 162 / 504 |
| blood vessel | 100% | 1874.79 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 54.86 | 79 / 80 |
| esophagus | 67% | 433.52 | 964 / 1445 | 31% | 6.12 | 57 / 183 |
| heart | 98% | 2107.55 | 840 / 861 | 0% | 0 | 0 / 0 |
| intestine | 78% | 424.23 | 758 / 966 | 16% | 2.86 | 86 / 527 |
| brain | 62% | 291.25 | 1625 / 2642 | 29% | 7.12 | 207 / 705 |
| adipose | 85% | 587.25 | 1023 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 49% | 241.95 | 176 / 359 | 24% | 4.09 | 68 / 286 |
| spleen | 66% | 239.91 | 158 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 25.65 | 26 / 45 |
| muscle | 19% | 112.00 | 153 / 803 | 0% | 0 | 0 / 0 |
| liver | 2% | 8.71 | 5 / 226 | 7% | 1.32 | 29 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.22 | 1 / 29 |
| peripheral blood | 1% | 1.74 | 5 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007088 | Biological process | regulation of mitotic nuclear division |
| GO_0000226 | Biological process | microtubule cytoskeleton organization |
| GO_0005813 | Cellular component | centrosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1990393 | Cellular component | 3M complex |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCDC8 |
| Protein name | Coiled-coil domain containing protein 8 Coiled-coil domain-containing protein 8 Coiled-coil domain containing 8 |
| Synonyms | |
| Description | FUNCTION: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer . Required for localization of CUL7 to the centrosome . . |
| Accessions | Q9H0W5 A0A8V8TMN3 A0A142DDU4 ENST00000307522.5 ENST00000697726.1 |
