CCDC65 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0003352Biological processregulation of cilium movement
GO_0070286Biological processaxonemal dynein complex assembly
GO_0060285Biological processcilium-dependent cell motility
GO_0005930Cellular componentaxoneme
GO_0031514Cellular componentmotile cilium
GO_0036064Cellular componentciliary basal body
GO_0005858Cellular componentaxonemal dynein complex
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameCCDC65
Protein nameDynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65) (Testis development protein NYD-SP28)
Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65)
Coiled-coil domain containing 65
SynonymsDRC2
DescriptionFUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules . .

AccessionsF8W0R6
F8VR42
ENST00000266984.9 [Q8IXS2-2]
ENST00000552942.5
ENST00000320516.5 [Q8IXS2-1]
Q8IXS2
ENST00000547861.5