CBR3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBR3 at tissue level.

III. Associated gene sets

GO_0050890Biological processcognition
GO_0042376Biological processphylloquinone catabolic process
GO_0006805Biological processxenobiotic metabolic process
GO_0005615Cellular componentextracellular space
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0004090Molecular functioncarbonyl reductase (NADPH) activity
GO_0008753Molecular functionNADPH dehydrogenase (quinone) activity
GO_0070402Molecular functionNADPH binding
GO_0005515Molecular functionprotein binding
GO_0000253Molecular function3-keto sterol reductase activity

IV. Literature review

[source]
Gene nameCBR3
Protein nameCarbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2)
SynonymsSDR21C2
DescriptionFUNCTION: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols . Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin . Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones . Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified . .

AccessionsO75828
ENST00000290354.6