CASTOR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904262Biological processnegative regulation of TORC1 signaling
GO_1903577Biological processcellular response to L-arginine
GO_0005829Cellular componentcytosol
GO_0061700Cellular componentGATOR2 complex
GO_0034618Molecular functionarginine binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASTOR2
Protein nameCytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2)
SynonymsGATSL1
GATSL2
DescriptionFUNCTION: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. .

AccessionsA6NHX0
ENST00000616305.2