CASTOR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CASTOR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASTOR1 at tissue level.

III. Associated gene sets

GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_1903577Biological processcellular response to L-arginine
GO_0005829Cellular componentcytosol
GO_0061700Cellular componentGATOR2 complex
GO_0034618Molecular functionarginine binding
GO_0140311Molecular functionprotein sequestering activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0140299Molecular functionsmall molecule sensor activity

IV. Literature review

[source]
Gene nameCASTOR1
Protein nameCytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)
Cytosolic arginine sensor for mTORC1 subunit 1 (GATS-like protein 3)
Cytosolic arginine sensor for mTORC1 subunit 1
SynonymsGATSL3
DescriptionFUNCTION: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway . As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1 . Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway . .

AccessionsF2Z2C1
F8WD52
Q8WTX7
ENST00000404953.7
ENST00000425691.5
H7C2U7
ENST00000421236.5
ENST00000415484.5
B7WPJ3
F2Z3I9
ENST00000440839.5
ENST00000407689.8
ENST00000440704.5