I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 13 studies | 29% ± 7% | |
| pericyte | 7 studies | 23% ± 5% | |
| cardiac muscle cell | 6 studies | 50% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 13 studies | 29% ± 7% | |
| pericyte | 7 studies | 23% ± 5% | |
| cardiac muscle cell | 6 studies | 50% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 3 studies | 25% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 81% | 5720.86 | 17 / 21 | 38% | 5.11 | 192 / 504 |
| esophagus | 63% | 4271.99 | 917 / 1445 | 46% | 3.84 | 84 / 183 |
| prostate | 17% | 735.54 | 41 / 245 | 85% | 6.62 | 429 / 502 |
| heart | 99% | 46989.14 | 853 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 13169.17 | 792 / 803 | 0% | 0 | 0 / 0 |
| intestine | 66% | 4329.06 | 633 / 966 | 31% | 2.40 | 166 / 527 |
| blood vessel | 89% | 13303.19 | 1187 / 1335 | 0% | 0 | 0 / 0 |
| breast | 28% | 713.27 | 128 / 459 | 58% | 2.28 | 652 / 1118 |
| uterus | 55% | 1578.68 | 93 / 170 | 25% | 21.02 | 115 / 459 |
| stomach | 31% | 1496.89 | 113 / 359 | 43% | 5.01 | 122 / 286 |
| thymus | 6% | 182.03 | 42 / 653 | 67% | 2.55 | 407 / 605 |
| kidney | 1% | 19.80 | 1 / 89 | 63% | 5.95 | 569 / 901 |
| adrenal gland | 0% | 7.63 | 1 / 258 | 62% | 4.16 | 143 / 230 |
| brain | 0% | 12.95 | 13 / 2642 | 51% | 1.38 | 357 / 705 |
| pancreas | 0% | 0 | 0 / 328 | 45% | 2.93 | 80 / 178 |
| lung | 10% | 267.72 | 56 / 578 | 33% | 1.85 | 385 / 1155 |
| skin | 3% | 90.79 | 57 / 1809 | 39% | 1.55 | 184 / 472 |
| liver | 0% | 0 | 0 / 226 | 42% | 1.02 | 170 / 406 |
| adipose | 38% | 1093.91 | 457 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 11% | 424.09 | 19 / 180 | 27% | 0.81 | 116 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 36% | 3.94 | 16 / 45 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.17 | 9 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.03 | 1 / 29 |
| spleen | 0% | 5.98 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0086029 | Biological process | Purkinje myocyte to ventricular cardiac muscle cell signaling |
| GO_0006941 | Biological process | striated muscle contraction |
| GO_0060315 | Biological process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| GO_0051208 | Biological process | sequestering of calcium ion |
| GO_0002027 | Biological process | regulation of heart rate |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0060048 | Biological process | cardiac muscle contraction |
| GO_0010881 | Biological process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| GO_0060306 | Biological process | regulation of membrane repolarization |
| GO_0051258 | Biological process | protein polymerization |
| GO_0043267 | Biological process | negative regulation of potassium ion transport |
| GO_0010649 | Biological process | regulation of cell communication by electrical coupling |
| GO_1901017 | Biological process | negative regulation of potassium ion transmembrane transporter activity |
| GO_0010880 | Biological process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| GO_0005513 | Biological process | detection of calcium ion |
| GO_0071313 | Biological process | cellular response to caffeine |
| GO_0030018 | Cellular component | Z disc |
| GO_0033018 | Cellular component | sarcoplasmic reticulum lumen |
| GO_0014701 | Cellular component | junctional sarcoplasmic reticulum membrane |
| GO_0034704 | Cellular component | calcium channel complex |
| GO_0016529 | Cellular component | sarcoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0140314 | Molecular function | calcium ion sequestering activity |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CASQ2 |
| Protein name | Calsequestrin Calsequestrin-2 (Calsequestrin, cardiac muscle isoform) Alternative protein CASQ2 |
| Synonyms | |
| Description | FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. . FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. . |
| Accessions | O14958 ENST00000261448.6 [O14958-1] ENST00000488931.2 L8EC86 A0AA34QVH1 |
