CASP14 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASP14 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	74%	37958.61	1341 / 1809	12%	33.90	56 / 472
prostate	53%	134.84	129 / 245	1%	0.11	3 / 502
breast	28%	19.88	128 / 459	25%	40.15	278 / 1118
uterus	9%	24.18	16 / 170	43%	161.74	198 / 459
pancreas	35%	53.44	114 / 328	14%	13.23	25 / 178
esophagus	27%	17.15	393 / 1445	17%	27.78	31 / 183
bladder	0%	0	0 / 21	32%	81.40	162 / 504
lung	14%	11.17	81 / 578	13%	10.31	145 / 1155
kidney	20%	10.83	18 / 89	3%	25.39	24 / 901
adipose	18%	70.86	220 / 1204	0%	0	0 / 0
blood vessel	18%	27.32	243 / 1335	0%	0	0 / 0
muscle	18%	22.40	146 / 803	0%	0	0 / 0
heart	17%	7.85	145 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	16%	109.94	7 / 45
peripheral blood	16%	7.14	144 / 929	0%	0	0 / 0
ovary	11%	4.66	19 / 180	3%	0.33	12 / 430
intestine	12%	6.06	115 / 966	1%	1.49	6 / 527
thymus	13%	6.57	82 / 653	0%	0	0 / 605
stomach	9%	3.76	32 / 359	0%	0	0 / 286
brain	8%	4.95	224 / 2642	0%	0	0 / 705
spleen	7%	2.42	17 / 241	0%	0	0 / 0
liver	6%	7.94	13 / 226	0%	0.03	2 / 406
adrenal gland	5%	2.90	14 / 258	0%	0	0 / 230
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0031424	Biological process	keratinization
GO_0008544	Biological process	epidermis development
GO_0070268	Biological process	cornification
GO_0006508	Biological process	proteolysis
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0001533	Cellular component	cornified envelope
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0045095	Cellular component	keratin filament
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding

Gene name	CASP14
Protein name	Caspase 14, apoptosis-related cysteine peptidase (Caspase-14) (cDNA, FLJ94644, Homo sapiens caspase 14, apoptosis-related cysteine protease(CASP14), mRNA) Caspase 14 Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
Synonyms	hCG_38589
Description	FUNCTION: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD . .
Accessions	B2CIS9 A9UFC0 ENST00000427043.4 P31944

CASP14 report