CAMSAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0022604Biological processregulation of cell morphogenesis
GO_0007010Biological processcytoskeleton organization
GO_0031113Biological processregulation of microtubule polymerization
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0031175Biological processneuron projection development
GO_0005815Cellular componentmicrotubule organizing center
GO_0036449Cellular componentmicrotubule minus-end
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0008017Molecular functionmicrotubule binding
GO_0005516Molecular functioncalmodulin binding
GO_0030507Molecular functionspectrin binding
GO_0051011Molecular functionmicrotubule minus-end binding

IV. Literature review

[source]
Gene nameCAMSAP1
Protein nameCAMSAP1 protein
Calmodulin-regulated spectrin-associated protein 1
Synonyms
DescriptionFUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization . Specifically recognizes growing microtubule minus-ends and stabilizes microtubules . Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization . In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation . Through interaction with spectrin may regulate neurite outgrowth . .

AccessionsENST00000409386.3 [Q5T5Y3-3]
Q5T5Y3
B7ZLW1
ENST00000389532.9 [Q5T5Y3-1]
ENST00000312405.10 [Q5T5Y3-2]