CALHM3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CALHM3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CALHM3 at tissue level.

III. Associated gene sets

GO_0070588Biological processcalcium ion transmembrane transport
GO_0051291Biological processprotein heterooligomerization
GO_0015867Biological processATP transport
GO_0050909Biological processsensory perception of taste
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005244Molecular functionvoltage-gated monoatomic ion channel activity
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity
GO_0005261Molecular functionmonoatomic cation channel activity

IV. Literature review

[source]
Gene nameCALHM3
Protein nameCalcium homeostasis modulator protein 3 (Protein A)
SynonymsFAM26A
DescriptionFUNCTION: Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. .

AccessionsQ86XJ0
ENST00000369783.4