CACNA1S report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CACNA1S at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CACNA1S at tissue level.

III. Associated gene sets

GO_0006941Biological processstriated muscle contraction
GO_0045933Biological processpositive regulation of muscle contraction
GO_0043501Biological processskeletal muscle adaptation
GO_0048741Biological processskeletal muscle fiber development
GO_0007029Biological processendoplasmic reticulum organization
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0002074Biological processextraocular skeletal muscle development
GO_0006936Biological processmuscle contraction
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0007528Biological processneuromuscular junction development
GO_0001501Biological processskeletal system development
GO_0007520Biological processmyoblast fusion
GO_0006816Biological processcalcium ion transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0071313Biological processcellular response to caffeine
GO_0005886Cellular componentplasma membrane
GO_1990454Cellular componentL-type voltage-gated calcium channel complex
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0030315Cellular componentT-tubule
GO_0031674Cellular componentI band
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0140677Molecular functionmolecular function activator activity
GO_0036094Molecular functionsmall molecule binding
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0046872Molecular functionmetal ion binding
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCACNA1S
Protein nameCalcium voltage-gated channel subunit alpha1 S
Voltage-dependent L-type calcium channel subunit alpha
Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)
SynonymsCACH1
CACN1
CACNL1A3
DescriptionFUNCTION: Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

AccessionsENST00000681190.1
ENST00000680059.1
A0A7P0T8M7
ENST00000681078.1
ENST00000681874.1
A0A7P0TB53
ENST00000679417.1
B1ALM3
ENST00000367338.7
A0A7P0Z433
ENST00000362061.4
A0A7P0TBR2
A0A7P0TBJ5
Q13698