C8G report

I. Expression across cell types

Insufficient scRNA-seq data for expression of C8G at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of C8G at tissue level.

III. Associated gene sets

GO_0031640Biological processkilling of cells of another organism
GO_0050778Biological processpositive regulation of immune response
GO_0006957Biological processcomplement activation, alternative pathway
GO_0006958Biological processcomplement activation, classical pathway
GO_0072562Cellular componentblood microparticle
GO_0070062Cellular componentextracellular exosome
GO_0005579Cellular componentmembrane attack complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0019841Molecular functionretinol binding
GO_0005515Molecular functionprotein binding
GO_0001848Molecular functioncomplement binding

IV. Literature review

[source]
Gene nameC8G
Protein nameComplement component C8 gamma chain
Complement C8 gamma chain
Synonyms
DescriptionFUNCTION: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

AccessionsP07360
ENST00000649480.1
ENST00000484376.1
ENST00000371634.7
A0A3B3ITK5
A0A3B3ITY0