C2CD2L report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of C2CD2L at tissue level.

III. Associated gene sets

GO_0120009Biological processintermembrane lipid transfer
GO_0015914Biological processphospholipid transport
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0032541Cellular componentcortical endoplasmic reticulum
GO_0098592Cellular componentcytoplasmic side of apical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0140268Cellular componentendoplasmic reticulum-plasma membrane contact site
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043559Molecular functioninsulin binding
GO_0008526Molecular functionphosphatidylinositol transfer activity
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameC2CD2L
Protein nameC2CD2 like
Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)
C2CD2L protein
SynonymsDLNB23
KIAA0285
TMEM24
DescriptionFUNCTION: Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane . It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling . Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers . In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane . Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules . .

AccessionsE9PK05
ENST00000528586.2
Q9BTM2
O14523
ENST00000336702.7 [O14523-2]
ENST00000648610.2 [O14523-1]
Q6DHX1