BRPF3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BRPF3 at tissue level.

III. Associated gene sets

GO_1903706Biological processregulation of hemopoiesis
GO_0050793Biological processregulation of developmental process
GO_0045740Biological processpositive regulation of DNA replication
GO_0006338Biological processchromatin remodeling
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070776Cellular componentMOZ/MORF histone acetyltransferase complex
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0043996Molecular functionhistone H4K8 acetyltransferase activity
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0043995Molecular functionhistone H4K5 acetyltransferase activity
GO_0036408Molecular functionhistone H3K14 acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameBRPF3
Protein nameBromodomain and PHD finger-containing protein 3
Bromodomain and PHD finger containing 3
BRPF3 protein
SynonymsKIAA1286
DescriptionFUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity . Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins . Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity . .

AccessionsH0Y7B4
F6XDC4
E9PI60
Q8N4T7
ENST00000532330.5
A8WI62
ENST00000527657.1
ENST00000449261.6
Q9ULD4
A8WI61
ENST00000441730.2
ENST00000534400.5
E9PJ12
E9PSF3
ENST00000534694.5 [Q9ULD4-3]
ENST00000446974.1
ENST00000441123.1
ENST00000454960.1
H0Y7I6
ENST00000339717.11 [Q9ULD4-2]
ENST00000357641.10 [Q9ULD4-1]