BRME1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BRME1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BRME1 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_0007144Biological processfemale meiosis I
GO_0005575Cellular componentcellular_component
GO_0005694Cellular componentchromosome
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameBRME1
Protein nameAlternative protein C19orf57
Break repair meiotic recombinase recruitment factor 1
Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3)
SynonymsC19orf57
DescriptionFUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. .

AccessionsENST00000586783.6 [Q0VDD7-1]
ENST00000672786.1 [Q0VDD7-2]
K7ELK3
Q0VDD7
ENST00000672170.1 [Q0VDD7-1]
ENST00000346736.6 [Q0VDD7-2]
L8EC49
ENST00000588115.5
K7EMZ7
ENST00000585755.1
ENST00000591586.5
K7EP60