BRDT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BRDT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BRDT at tissue level.

III. Associated gene sets

GO_0043484Biological processregulation of RNA splicing
GO_0010628Biological processpositive regulation of gene expression
GO_0035092Biological processsperm DNA condensation
GO_0008380Biological processRNA splicing
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006397Biological processmRNA processing
GO_0006338Biological processchromatin remodeling
GO_0007140Biological processmale meiotic nuclear division
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007141Biological processmale meiosis I
GO_0005634Cellular componentnucleus
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0140566Molecular functionhistone reader activity
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameBRDT
Protein nameBromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein)
Bromodomain testis associated
Synonyms
DescriptionFUNCTION: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis . Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time . In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA . Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. .

AccessionsC9JD82
C9JDL5
Q58F21
ENST00000470955.6
ENST00000680194.1
ENST00000448194.6
ENST00000402388.1 [Q58F21-1]
C9J0Z0
ENST00000548992.5
C9JJU3
ENST00000427104.5
A0A7P0T8B0
C9JLZ2
A0A7P0TAR6
ENST00000680091.1
A0A7P0TB14
ENST00000370389.6 [Q58F21-5]
ENST00000457265.1
ENST00000552654.1
ENST00000362005.7 [Q58F21-1]
A0A7P0TAQ7
F8W0H2
ENST00000449584.5
C9J3A0
ENST00000680541.1
ENST00000426141.6
ENST00000450792.5
F8VZ63
ENST00000399546.7 [Q58F21-1]
ENST00000355011.7
C9J1F7
C9JQ27
ENST00000440509.5
ENST00000394530.7 [Q58F21-4]
C9JMP1
ENST00000423434.5