BRCC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010165Biological processresponse to X-ray
GO_0010212Biological processresponse to ionizing radiation
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0045739Biological processpositive regulation of DNA repair
GO_0006302Biological processdouble-strand break repair
GO_0006282Biological processregulation of DNA repair
GO_0051301Biological processcell division
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0006508Biological processproteolysis
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0071479Biological processcellular response to ionizing radiation
GO_0000151Cellular componentubiquitin ligase complex
GO_0000922Cellular componentspindle pole
GO_0005654Cellular componentnucleoplasm
GO_0070531Cellular componentBRCA1-A complex
GO_0070552Cellular componentBRISC complex
GO_0005829Cellular componentcytosol
GO_0000152Cellular componentnuclear ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140492Molecular functionmetal-dependent deubiquitinase activity
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0046872Molecular functionmetal ion binding
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBRCC3
Protein nameBRCA1/BRCA2-containing complex subunit 3
Lys-63-specific deubiquitinase (EC 3.4.19.-)
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
SynonymsC6.1A
BRCC36
CXorf53
DescriptionFUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains . Does not have activity toward 'Lys-48'-linked polyubiquitin chains . Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) . Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates . Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex . The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression . Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination . Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). .

FUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. .

AccessionsH7C413
ENST00000330045.12 [P46736-2]
ENST00000340647.8 [P46736-3]
P46736
ENST00000453705.1
ENST00000411985.5
ENST00000369462.5 [P46736-1]
A0A0A0MS96
ENST00000369459.6 [P46736-5]
X6RJS7
ENST00000399026.1