BPI | OmnibusX

Name	Number of supported studies	Average coverage
neutrophil	3 studies	24% ± 2%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of BPI at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	98%	197.54	176 / 180	8%	0.33	34 / 430
uterus	92%	100.19	157 / 170	6%	0.14	29 / 459
spleen	98%	1074.64	235 / 241	0%	0	0 / 0
lung	88%	295.54	511 / 578	4%	0.18	43 / 1155
kidney	82%	64.78	73 / 89	5%	0.16	49 / 901
peripheral blood	81%	6121.79	756 / 929	0%	0	0 / 0
prostate	76%	51.52	186 / 245	3%	0.04	16 / 502
blood vessel	75%	50.17	1000 / 1335	0%	0	0 / 0
breast	58%	33.71	267 / 459	15%	1.26	171 / 1118
liver	51%	35.40	115 / 226	4%	0.54	17 / 406
adipose	52%	30.89	630 / 1204	0%	0	0 / 0
thymus	48%	24.04	315 / 653	1%	0.02	5 / 605
intestine	45%	19.55	431 / 966	3%	0.05	14 / 527
bladder	43%	15.95	9 / 21	1%	0.03	7 / 504
heart	44%	26.82	378 / 861	0%	0	0 / 0
esophagus	38%	16.64	546 / 1445	4%	0.14	8 / 183
stomach	25%	13.23	91 / 359	7%	0.14	19 / 286
adrenal gland	28%	15.02	71 / 258	2%	0.06	4 / 230
brain	24%	8.93	639 / 2642	5%	0.09	33 / 705
pancreas	2%	0.83	8 / 328	14%	0.52	25 / 178
lymph node	0%	0	0 / 0	14%	0.26	4 / 29
skin	2%	0.57	29 / 1809	12%	0.69	57 / 472
muscle	8%	3.07	64 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.07	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0043031	Biological process	negative regulation of macrophage activation
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0032717	Biological process	negative regulation of interleukin-8 production
GO_0045087	Biological process	innate immune response
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0035580	Cellular component	specific granule lumen
GO_0001530	Molecular function	lipopolysaccharide binding

Gene name	BPI
Protein name	Bactericidal permeability-increasing protein (BPI) Bactericidal permeability increasing protein Bactericidal permeability-increasing protein (BPI) (CAP 57)
Synonyms
Description	FUNCTION: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. . FUNCTION: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. . FUNCTION: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. .
Accessions	A0A0D9SFX6 ENST00000642449.2 P17213 ENST00000417318.3 H0Y738 A0A2R8YDF1 ENST00000262865.9 ENST00000489102.2

BPI report