BICDL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055107Biological processGolgi to secretory granule transport
GO_0047496Biological processvesicle transport along microtubule
GO_0031175Biological processneuron projection development
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0034452Molecular functiondynactin binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameBICDL1
Protein nameBICD family like cargo adaptor 1
BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (CCDC64A)
SynonymsCCDC64
BICDR1
DescriptionFUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. .

AccessionsENST00000546420.5
ENST00000397558.6 [Q6ZP65-1]
H0YHW1
ENST00000548673.6
H0YHP2
Q6ZP65
ENST00000547841.1
H0YIC1