I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 4 studies | 35% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| goblet cell | 4 studies | 35% ± 15% |
Insufficient scRNA-seq data for expression of BEST2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 66% | 2048.76 | 636 / 966 | 38% | 3.05 | 201 / 527 |
| skin | 71% | 992.73 | 1292 / 1809 | 1% | 0.02 | 3 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 5.55 | 15 / 45 |
| stomach | 0% | 0.16 | 1 / 359 | 24% | 1.82 | 69 / 286 |
| esophagus | 7% | 3.27 | 105 / 1445 | 14% | 0.66 | 25 / 183 |
| bladder | 0% | 0 | 0 / 21 | 15% | 0.88 | 77 / 504 |
| uterus | 2% | 1.08 | 4 / 170 | 12% | 0.63 | 55 / 459 |
| muscle | 6% | 1.64 | 48 / 803 | 0% | 0 | 0 / 0 |
| lung | 1% | 0.34 | 5 / 578 | 4% | 0.30 | 51 / 1155 |
| brain | 4% | 1.42 | 113 / 2642 | 1% | 0.01 | 4 / 705 |
| peripheral blood | 4% | 0.93 | 35 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.12 | 3 / 80 |
| adipose | 4% | 1.56 | 44 / 1204 | 0% | 0 | 0 / 0 |
| breast | 3% | 7.85 | 13 / 459 | 0% | 0.01 | 3 / 1118 |
| prostate | 2% | 1.38 | 6 / 245 | 1% | 0.02 | 3 / 502 |
| ovary | 0% | 0 | 0 / 180 | 3% | 0.07 | 13 / 430 |
| pancreas | 0% | 0.12 | 1 / 328 | 2% | 0.15 | 4 / 178 |
| thymus | 2% | 0.33 | 10 / 653 | 1% | 0.01 | 4 / 605 |
| kidney | 1% | 0.29 | 1 / 89 | 0% | 0.01 | 3 / 901 |
| liver | 0% | 0.26 | 1 / 226 | 0% | 0.01 | 2 / 406 |
| spleen | 1% | 0.19 | 2 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 0.23 | 11 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.08 | 4 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0.09 | 1 / 258 | 0% | 0 | 0 / 230 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051899 | Biological process | membrane depolarization |
| GO_0007608 | Biological process | sensory perception of smell |
| GO_0015701 | Biological process | bicarbonate transport |
| GO_0098655 | Biological process | monoatomic cation transmembrane transport |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0008150 | Biological process | biological_process |
| GO_0005929 | Cellular component | cilium |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005217 | Molecular function | intracellularly ligand-gated monoatomic ion channel activity |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0099094 | Molecular function | ligand-gated monoatomic cation channel activity |
| GO_0099095 | Molecular function | ligand-gated monoatomic anion channel activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0160133 | Molecular function | bicarbonate channel activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003674 | Molecular function | molecular_function |
| Gene name | BEST2 |
| Protein name | Bestrophin Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1) |
| Synonyms | VMD2L1 |
| Description | FUNCTION: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. . FUNCTION: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. . |
| Accessions | ENST00000553030.6 ENST00000042931.1 ENST00000549706.5 Q8NFU1 ENST00000552539.1 H0YIH1 |
